On July 17-19, 2018, the Department of the Interior (DOI) Strategic Sciences Group (SSG) convened a multidisciplinary group of experts in Hilo, Hawai’i, to consider the cascading consequences of the 2018 Kilauea eruption to DOI resources, employees, and facilities as well as to the surrounding communities. The team developed scenarios to identify potential actions and known knowledge gaps to mitigate the negative effects of the eruption. This activation of the SSG was supported by the US Geological Survey (USGS).